GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs12220238 | 1 | rs10824130 | chr10:76008931 | ADK | chr10:75910965-76469059:+ | 0.27 | 4.21 | 3.23E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs12220238 | 1 | rs10824151 | chr10:76092179 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.49 | 9.5E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs10508921 | 1 | rs10825492 | chr10:52008730 | FAM21A | chr10:51827684-51893268:+ | -0.36 | -4.37 | 1.58E-5 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| BLCA | cis | rs9783347 | 1 | rs10832921 | chr11:18380835 | GTF2H1 | chr11:18343816-18388590:+ | 0.29 | 5.51 | 6.75E-8 | Pancreatic cancer |
| BLCA | cis | rs7927771 | 1 | rs10838738 | chr11:47663049 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.73 | 2.07E-8 | Subjective well-being |
| BLCA | cis | rs7927771 | 1 | rs10838747 | chr11:47716324 | C1QTNF4 | chr11:47611216-47615961:- | -0.29 | -5.61 | 3.99E-8 | Subjective well-being |
| BLCA | cis | rs7927771 | 1 | rs10838748 | chr11:47716381 | C1QTNF4 | chr11:47611216-47615961:- | -0.29 | -5.65 | 3.1E-8 | Subjective well-being |
| BLCA | cis | rs7927771 | 1 | rs10838757 | chr11:47763016 | C1QTNF4 | chr11:47611216-47615961:- | -0.3 | -5.66 | 2.93E-8 | Subjective well-being |
| BLCA | cis | rs10849605 | 1 | rs10849605 | chr12:1064438 | RAD52 | chr12:1021255-1099219:- | -0.19 | -3.88 | 0.000125 | Lung cancer |
| BLCA | cis | rs2275426 | 1 | rs1085243 | chr1:46544768 | CCDC163P | chr1:45960581-45965646:- | -0.33 | -6.22 | 1.28E-9 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs1085243 | chr1:46544768 | MUTYH | chr1:45794915-45806142:- | 0.2 | 3.9 | 0.000115 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs1085244 | chr1:46563680 | CCDC163P | chr1:45960581-45965646:- | -0.33 | -6.21 | 1.42E-9 | Body mass index |
| BLCA | cis | rs10853057 | 1 | rs10853057 | chr17:62998023 | AMZ2P1 | chr17:62962668-62971703:- | 0.54 | 6.57 | 1.63E-10 | White matter microstructure (global fractional anisotropy) |
| BLCA | cis | rs4803468 | 1 | rs10853751 | chr19:41903220 | B3GNT8 | chr19:41931265-41934635:- | -0.21 | -4.04 | 6.41E-5 | Height |
| BLCA | cis | rs9815354 | 1 | rs10865914 | chr3:41919499 | ULK4 | chr3:41288091-42003660:- | -0.64 | -9.91 | 9.53E-21 | Diastolic blood pressure |